Antibiotic Resistance: Prevention Mechanisms and control organisms

Antibiotic resistance is increased by the dissipate and overuse of antibiotics, as well as poor infection prevention and control. Steps can be taken at all levels of society to decrease the impact and limit the spread of resistance.

To prevent and control the circulate of antibiotic resistance, individuals can:

  • Only use antibiotics when recommended by a certified health professional.
  • Never demand antibiotics if your health worker announces you don’t need them.
  • Always follow your health worker’s guidance when using antibiotics.
  • Never share or use leftover antibiotics.
  • Prevent infections by frequently washing hands, making healthy food, avoiding close contact with sick people, practicing safer sex, and keeping vaccinations up to date.
  • Prepare healthy food, following the WHO Five Keys to Safer Food (keep clean, separate organic and cooked, cook thoroughly, place food at secure temperatures, use safe water and organic materials) and prefer foods that have been produced without the use of antibiotics for growth promotion or disease prevention in healthy animals.

Resistance to antibiotics can be produced by four general mechanisms:

  • The inactivation or modification of the antibiotic;
  • An alteration in the aim site of the antibiotic that decreases its binding capacity;
  • The adjustment of metabolic pathways to circumvent the antibiotic effect;
  • The decreased intracellular antibiotic accumulation by decreasing permeability and/or increasing active efflux of the antibiotic.

  • Genetic Basis Of Antimicrobial Resistance
  • Mechanistic Basis Of Antimicrobial Resistance
  • Antibiotic Modification or Degradation
  • Target Modification/Bypass/Protection Mechanisms

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